THE ANTIMICROBIAL ACTION OF LISTERINE® ANTISEPTIC COMES FROM ITS UNIQUE FORMULA, WHICH CONTAINS A FIXED COMBINATION OF 4 ESSENTIAL OILS FOUND IN NATURAL PLANT SOURCES.

WHAT DOES LISTERINE^® DO?

• LISTERINE^® Mouthwash reaches every site in the mouth, reducing plaque biofilm in areas that patients may miss when brushing and interdental cleaning
• The 4 essential oils in LISTERINE^® penetrate deeply into the bottom layers of the plaque biofilm, breaking down its structure in places that are more difficult for a toothbrush or interdental cleaning device to access^1-3

A BOLD ACHIEVEMENT: BETTER PLAQUE REDUCTION THAN CPC.⁴

• LISTERINE^® Antiseptic penetrates deeper into the plaque biofilm than cetylpyridinium chloride (CPC) mouthrinse
• Confocal microscopy reveals a higher ratio of dead bacteria to living bacteria within the biofilm with LISTERINE^® than with CPC mouthrinse or negative control

THE 4 ESSENTIAL OILS IN LISTERINE® KILL 1.8X MORE BACTERIA THAN CPC MOUTHRINSES.⁴

*Based on self-reported data from a survey of patients in Brazil, Japan, Thailand, United Kingdom, and United States (N=4134).

References: 1. Foster JS, Pan PC, Kolenbrander PE. Effects of antimicrobial agents on oral biofilms in a saliva-conditioned flowcell. Biofilms. 2004;1(1):3-10. 2. Minah GE, DePaola LG, Overholser CD, et al. Effects of 6 months use of an antiseptic mouthrinse on supragingival dental plaque microflora. J Clin Periodontol. 1989;16(6):347-352. 3. Walker C, Clark W, Wheeler T, Lamm R. Evaluation of microbial shifts in supragingival plaque following long-term use of an oral antiseptic mouthrinse. J Dent Res. 1989;68:412. 4. Fine DH et al. Effect of rinsing with an essential oil-containing mouthrinse on subgingival periodontopathogens. J Periodontol. 2007;78 (10): 1935-1942.