LISTERINE® has been available for decades, the original formulation having been available throughout the 1900s, and therefore there is a substantial evidence base for its use. LISTERINE® has been the focus of much clinical research; with more than thirty long-term studies having been conducted over the last forty years.
LISTERINE®, when added to mechanical cleaning, has been shown to reduce plaque accumulation, leading to significant reductions in gingivitis levels compared to brushing and flossing alone.1 LISTERINE®'s mode of action is well understood, with its four Essential Oils penetrating the biofilm2 and killing up to 97% of oral bacteria left behind after brushing3
LISTERINE® Total Care products build upon the proven science of the plaque-reducing Essential Oils, and all contain fluoride.
The majority of the LISTERINE® range contains four Essential Oils, which are antibacterial antiplaque agents, and are proven to penetrate the biofilm. The oils are eucalyptol, thymol, methyl salicylate and menthol. The LISTERINE® Total Care products also contain 220 ppm fluoride
- Sharma NC et al. Adjunctive benefit of an essential oil containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly. A six-month study. J Am Dent Assoc 2004; 135: 496–504.
- Fine DH et al. Comparative antimicrobial activities of antiseptic mouthrinses against isogenic planktonic and biofilm forms of Actinobacillus actinomycetemcomitans. J Clin Periodontol 2001; 28: 697–700.
- Data on file, FCLGBP0023, McNeil-PPC, Inc.